Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes
نویسندگان
چکیده
منابع مشابه
Silyl Migrations of Various 3 " [ ( Trialkylsilyl ) - Oxymethyl ] - Furans and - Thiophenes
That 3-[(t-butyldimethylsilyl)oxymethyl]furan 1_ can be lithiated at C-2 (n-BuLi/ether/r.t./6hj and the resulting anion quenched with electrophiles is well known. Treatment of the above anion with 1-bromo-3-chloropropane result ed in a poor yield of 2_; however, changing the reaction conditions (n-BuLi/THF 0°C/6h) and then adding HMPA with the electrophile resulted in the isolation o 1 (h0% by ...
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2-(methylthio)-1,4-diaryl-2-butene-1,4-dione (3) are prepared from readily available aryl methyl ketones in the presence of copper(II) oxide, iodine, and dimethyl sulfoxide. The success of the cross-coupling reaction of 4-chloroacetophenone with 2-acetylthiophene confirms a proposed self-sorting tandem reaction mechanism. Both Z- and E-isomers of compound 3 are readily converted into the corres...
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The composition of non-methane organic volatile compounds (VOCs) determined in 139 thermal gas discharges from 18 different geothermal and volcanic systems in Italy and Latin America, consists of C(2)-C(20) species pertaining to the alkanes, alkenes, aromatics and O-, S- and N-bearing classes of compounds. Thiophenes and mono-aromatics, especially the methylated species, are strongly enriched i...
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The addition of heteroaryllithium to various ketones followed by dehydration gave 1-(2-heteroaryl)cycloalkenes and (2-hetero- aryl)alkenes. When alkenes were treated with 10 mol% NIS, calix[4]thiophenes and calix[4]furans were obtained in good yields.
متن کاملCopper-promoted hydration and annulation of 2-fluorophenylacetylene derivatives: from alkynes to benzo[b]furans and benzo[b]thiophenes
An efficient copper-promoted hydration reaction and its application in the synthesis of benzo[b]furan and benzo[b]thiophene derivatives is presented starting from readily available 2-fluorophenylacetylene derivatives. The key annulation step involves the hydration of the C-F bond of 2-fluorophenylacetylene derivatives followed by an intramolecular annulation to afford benzo[b]furan and benzo[b]...
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ژورنال
عنوان ژورنال: Chemical Research in Toxicology
سال: 2017
ISSN: 0893-228X,1520-5010
DOI: 10.1021/acs.chemrestox.6b00336